肖鹏，山东大学基础医学院教授，博士生导师 国家自然科学基金优秀青年基金获得者；山东省“泰山学者”青年专家，山东省 优秀青年基金获得者；山东大学杰出中青年；山东大学“齐鲁青年学者”；山东 大学“未来学者”，山东大学基础医学院生物化学与分子生物学系主任。

研究方向：重大疾病靶标G蛋白偶联受体（GPCR）进行结构与功能研究及天然产物筛选

目前取得了系列创新性学术成绩：1）阐明 重要神经递质多巴胺受体的配体识别及激活机制，建立了GPCR调控Arrestin的 “码头分选”模型（Cell, 2021；Nat Chem Biol, 2018；Nat Commun, 2021）；2） 解析了具有神经活性脂类（固醇类和脂肪酸类）激素的识别机制，发现神经系 统疾病治疗的GPCR新靶点（Proc Natl Acad Sci USA, 2022; Nature, 2021; Nature, 2020; Sci Adv, 2021）；3）开发了靶向GPCR和下游磷酸化网络治疗神经系统疾病 的干预策略（Nature, 2022a; Nature, 2022b；J Neurochem, 2019; J Cell Mol Med, 2020; J Biol Chem, 2018;等）。迄今为止，在Cell、Nature (4篇)、Nat Chem Biol、PNAS等高水平期刊共发表学术论文32篇（含已接收）。其中以第一或通讯 作者（含共）发表论文19篇，包括4篇Nature (2022a; 2022b; 2021; 2020)，1篇Cell (2021)，2篇Nat Chem Biol (2018, 2022)，1篇Nature Commun (2021)，1篇Sci Adv (2021)。共主持国家自然科学基金项目2项，国家重点研发计划子课题2项 （项目骨干），山东省自然科学基金3项；担任中国药理学会生化与分子药理学专 业委员会委员，山东生物化学与分子生物学会理事。

教育经历

2006/7–2012/6，山东大学（UW-Madison美国威斯康星大学麦迪逊分校联合培养），生化与分子生物学，博士，导师：汪天虹/JaeHyuk Yu

2002/9–2006/7，山东大学，生命科学， 学士， 导师：汪天虹 

科研与学术工作经历

2020/09-至今，山东大学基础医学院，研究员 

2019/09-2020/09，山东大学基础医学院，副教授 

2012/7-2018/08，山东大学基础医学院，讲师 

主持科研项目 

1. 国家自然科学基金优秀青年基金，32222038, 神经系统GPCR结构与功能, 2023.01.01-2025.12.31，200万元，课题负责人

2. 国家重点研发计划，2019YFA0904200，基于基因密码子扩展技术的非天然 真核系统的构建及其应用，2020.01.01-2024.12.31，45.32万元，项目骨干。

3. 国家自然科学基金面上项目, 31971195, CRHR2偏向性配体的发展和信号转 导复合物的结构基础, 2020.01.01-2023.12.31，63.51万元，课题负责人。

4. 国家重点研发计划青年项目，2019YFA0508801，组胺H3R精准调控神经干 细胞特化的机制研究及其药物发现，2019.11.01-2024.10.31，75.2万元，项目 骨干。

5. 国家自然科学基金青年项目，31700692，酪氨酸磷酸酶PTP1B和LYP催化活 性中心第二层氨基酸的功能研究，2018/01-2020/12，25万元，课题负责人；

6. 山东省重点研发计划，2018GSF118147，磷酸酶Slingshot催化机制、结构基 础的研究和抑制剂的筛选，2018.04.01-2020.12.31，10万元，课题负责人；

7. 山东省自然科学基金委，ZR2021YQ18，G蛋白偶联受体信号转导复合物结 构和功能研究，2022.01.01-2024.12.31，45万元，课题负责人；

8. 山东大学齐鲁青年学者建设经费，2022.01.01-2026.12.31，60万，课题负责人；

9. 山东大学未来学者建设经费，2019.01.01-2021.12.31，50万，课题负责人；

代表性论文 

第一作者或共同一作文章 ( #第一作者, *通讯作者) 

1. An W# , Lin H# , Ma L# , Zhang C, Zheng Y, Cheng Q, Ma C, Wu X, Zhang Z, Zhong Y, Wang M, He D, Yang Z, Du L, Feng S, Wang C, Yang F, Xiao P*, Zhang P*, Yu X *, Sun JP*. Progesterone activates GPR126 to promote breast cancer development via the Gi pathway. Proc Natl Acad Sci USA 2022 119(15):e2117004119.

2. Xiao P# , Yan W# , Gou L# , Zhong YN# , Kong L# , Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang CC, Xia A, Hu Z, Zhang Q, He YH, Zhang DL, Zhang C, Hou GH, Liu H, Zhu L, Fu P, Yang S, Rosenbaum D, Sun JP*, Du Y*, Zhang L*, Yu X*, Shao Z*. Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes. Cell 2021 Feb 18;184(4):943-956. (IF: 38.83, 封面文章; Nature Reviews Drug Discovery 推荐)

3. Xiao P# , Guo SC# , Wen X# , He QT# , Lin H# , Huang SM# , Gou L# , Zhang C, Yang Z, Zhong YN, Yang CC, Li Y, Li SL, Tao XN, Yang ZS, Lu Y, He JY, Wang CX, Zhang L*, Kong LL*, Sun JP*, Yu X*. Tethered peptide activation mechanism of adhesion GPCRs ADGRG2 and ADGRG4. Nature 2022 604(7907):771-778(Nature 杂志同期评 述).

4. Ping Y# , Xiao P# , Yang F# , Zhao RJ# , Guo SC# , Wu X# , Yan X# , Yang Z, An WT, Shen DD, Yang F, Zhang H, Qu C, Li ZJ, Shen Q, Tian C, Li S, Wang GY, Tao X, Wen X, Zhong YN, Yang J, Yi F, Yu X, Xu HE*, Zhang Y*, Sun JP*. Structural basis for the tethered peptide activation of adhesion GPCRs. Nature 2022 604(7907):763-770 (Nature 杂志同期评述).

5. Yuqi Ping# , Chunyou Mao# , Peng Xiao# , Ru-Jia Zhao# , Yi Jiang# , Zhao Yang, Wen-Tao An, Dan-Dan Shen, Fan Yang, Huibing Zhang, Changxiu Qu, Zi-jian Li, Qingya Shen, Caiping Tian, Shaolong Li, Guang-Yu Wang, Xiaona Tao, Xin Wen, Ya-Ni Zhong, Jing Yang, Fan Yi, Xiao Yu, H. Eric Xu, Yan Zhang, Jin-Peng Sun. Structures of glucocorticoid-bound adhesion receptor GPR97-Go complex. Nature. 2021 Jan;589 (7843):620-626. (IF: 42.778；Faculty 1000 推荐)

6. Fan Yang# , Chunyou Mao# , Lulu Guo# , Jingyu Lin# , Qianqian Ming# , Peng Xiao# , Xiang Wu# , Qingya Shen, Shimeng Guo, Dan-Dan Shen, Ruirui Lu, Linqi Zhang, Shenming Huang, Yuqi Ping, Chenlu Zhang, Cheng Ma, Kai Zhang, Xiaoying Liang, Yuemao Shen, Fajun Nan, Fan Yi, Vincent C Luca, Jiuyao Zhou, Changtao Jiang, Jin-Peng Sun*, Xin Xie*, Xiao Yu*, Yan Zhang*. Structural basis of GPBAR activation and bile acid recognition. Nature. 2020 Nov;587(7834):499-504 (IF: 42.778)

7. Fan Yang# , Peng Xiao# , Chang-xiu Qu# , Qi Liu# , Liu-yang Wang, Zhi-xin Liu, Qing-tao He, Chuan Liu, Jian-ye Xu, Rui-rui Li, Meng-jing Li, Qing Li, Xu-zhen Guo, Dong-fang He, Fan Yi, Ka-Young Chuang, Ke Ruan, Yue-mao Shen, Xiao Yu, Jin-peng Sun* & Jiang-yun Wang*. Allosteric mechanisms underlie GPCR signalling to SH3-domain proteins through arrestin. Nature Chemical Biology. 2018, 14(9):876-886. (IF: 12.587)

8. Hui Lin# , Peng Xiao# , Rui-Qian Bu# , Shengchao Guo# , Zhao Yang# , Daopeng Yuan# , Zhong-Liang Zhu, Chuan-Xin Zhang, Qing-Tao He, Chao Zhang, Yu-Qi Ping, Ru-Jia Zhao, Chuan-Shun Ma, Chang-Hao Liu, Xiao-Ning Zhang, Dan Jiang, Shaohui Huang, Yue-Tong Xi, Dao-Lai Zhang, Chen-Yang Xue, Bai-Sheng Yang, Jian-Yuan Li, Hao-Cheng Lin, Xu-Hui Zeng, Han Zhao, Wen-Ming Xu, Fan Yi* , Zhongmin Liu* , Jin-Peng Sun* , Xiao Yu* Structures of the ADGRG2-Gs complex in apo and ligand bound forms. Nature Chemical Biology. 2022(Accepted)

9. Qu C# , Mao C# , Xiao P# , Shen Q# , Zhong YN# , Yang F# , Shen DD, Tao X, Zhang H, Yan X, Zhao RJ, He J, Guan Y, Zhang C, Hou Guihua, Zhang PJ, Hou Guige, Li Z, Yu X, Chai RJ*, Guan YF,10 Sun JP*, Zhang Y*. Ligand recognition, unconventional activation and G protein coupling of the prostaglandin E2 receptor 2. Science Advances 2021, Apr 2;7(14):eabf1268. (IF: 14.09)

10. He QT, Xiao P# , Huang SM, Jia YL, Zhu ZL, Lin JY, Yang F, Tao XN, Zhao RJ, Gao FY, Niu XG, Xiao KH, Wang JY*, Jin CW*, Sun JP*, Yu X*. Structural studies of phosphorylation-dependent interactions between the V2R receptor and arrestin-2. Nature Commun 2021, Apr 22;12(1):2396. (IF 13.610).

11. Shen-Ming Huang# , Peng Xiao# . Structural basis of signaling of cannabinoids receptors: paving a way for rational drug design in controling mutiple neurological and immune diseases. Signal Transduct and Target Ther. 2020, 5(1):127. (IF: 13.195)

12. Zhiyuan Lu# , Peng Xiao# , Yuan Zhou, Zhenyu Li, Xiao Yu, Jin-Peng Sun, Yuemao Shen, Baobing Zhao. Identification of HN252 as a potent inhibitor of protein phosphatase PPM1B. J Cell Mol Med. 2020 doi: 10.1111/jcmm.15975.

13. Yang D# , Xiao P# , Li Q# , Fu X, Pan C, Lu D, Wen S, Xia W, He, Li H, Fang H, Shen Y, Xu X, Lin A, Wang C, Yu X, Wu J*, Sun J*. Allosteric modulation of the catalytic VYD loop in Slingshot by its N-terminal domain underlies both Slingshot auto-inhibition and activation. J Biol Chem. 2018, 293(42):16226-16241. (IF:4.238)

14. Qiu-Yu Gong# , Wenqing Qing# , Peng Xiao# . Internal standard fluorogenic probe based on vibration-induced emission for visualizing PTP1B in living cells. Chem Commun (Camb). 2019 56(1):58-61. (IF: 5.989)

15. Meisam Rostaminasab Dolatabad# , Lulu Guo# , Peng Xiao# , Zhongliang Zhu, Qingtao He, DuxiaoYang, Changxiu Qu, Shengchao Guo, Xiaolei Fu, Ruirui Li, Lin Ge, Kejia Hu, Hongda Liu, Yuemao Shen, Xiao Yu, Jinpeng Sun*, Pengju Zhang*. Crystal structure and catalytic activity of the PPM1K N94K mutant. J Neurochem. 2019, 148(4):550-560. (IF: 4.066)

16. Kang-shuai Li# , Peng Xiao# , Dao-lai Zhang, Xu-Ben Hou, Lin Ge, Du-xiao Yang, Hong-da Liu, Dong-fang He, Xu Chen, Ke-rui Han, Xiao-yuan Song, Xiao Yu, Hao Fang, Jin-peng Sun. Identification of para-Substituted Benzoic Acid Derivatives as Potent Inhibitors of the Protein Phosphatase Slingshot. ChemMedChem. 2015 Dec;10(12):1980-7.

17. Peng Xiao# , Xiao Wang# , Hong-Mei Wang, Xiao-Lei Fu, Fu-ai Cui, Xiao Yu, Shi-shuai Wen, Wen-Xiang Bi*, Jin-Peng Sun*. The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop. Int J Biochem Cell Biol. 2014, 57:84-95. (IF: 3.673)

18. Peng Xiao, Shin KS, Wang T*, Yu JH*. Aspergillus fumigatus flbB encodes two basic leucine zipper domain (bZIP) proteins required for proper asexual development and gliotoxin production, Eukaryot Cell. 2010, 9(11):1711-1723.

19. 肖鹏, 孙金鹏, 裴钢, 新生物学年鉴 2013（G 蛋白偶联受体结构分析的近年进展）

其他作者文章

20. Qi Liu, Qing-Tao He, Xiaoxuan Lyu, Fan Yang, Zhong-Liang Zhu, Peng Xiao, Zhao Yang, Feng Zhang, Zhao-Ya Yang, Xiao-Yan Wang, Peng Sun, Qian-Wen Wang, Chang-Xiu Qu, Zheng Gong, Jing-Yu Lin, Zhen Xu, Shao-le Song, Shen-Ming Huang, Sheng-Chao Guo, Ming-Jie Han, Kong-Kai Zhu, Xin Chen, Alem W Kahsai, Kun-Hong Xiao, Wei Kong, Fa-Hui Li, Ke Ruan, Zi-Jian Li, Xiao Yu, Xiao-Gang Niu, Chang-Wen Jin, Jiangyun Wang, Jin-Peng Sun. DeSiphering receptor core-induced and ligand-dependent conformational changes in arrestin via genetic encoded trimethylsilyl 1H-NMR probe. Nat Commun. 2020 Sep 25;11(1):4857. 

21. Xiao Liang, Huansheng Fu, Peng Xiao, Hao Fang, Xuben Hou. Design, synthesis and biological evaluation of imidazolidine-2,4-dione and 2-thioxothiazolidin-4-one derivatives as lymphoid-specific tyrosine phosphatase inhibitors. Bioorg Chem. 2020 Oct;103:104124. 

22. Kangshuai Li, Xuben Hou, Ruirui Li, Wenxiang Bi, Fan Yang, Xu Chen, Peng Xiao, Tiantian Liu, Tiange Lu, Yuan Zhou, Zhaomei Tian, Yuemao Shen, Yingkai Zhang, Jiangyun Wang, Hao Fang, Jinpeng Sun, Xiao Yu. Identification and structure-function analyses of an allosteric inhibitor of the tyrosine phosphatase PTPN22.J Biol Chem.2019 May 24;294(21):8653-8663.

23. Xuben Hou, David Rooklin, Duxiao Yang, Xiao Liang, Kangshuai Li, Jianing Lu, Cheng Wang, Peng Xiao, Yingkai Zhang, Jin-Peng Sun, Hao Fang. Computational Strategy for Bound State Structure Prediction in Structure-Based Virtual Screening: A Case Study of Protein Tyrosine Phosphatase Receptor Type O Inhibitors.J Chem Inf Model.2018 Nov 26;58(11):2331-2342.

24. Hui Li, Duxiao Yang, Shanglei Ning, Yinghui Xu, Fan Yang, Rusha Yin, Taihu Feng, Shouqing Han, Lu Guo, Pengju Zhang, Wenjie Qu, Renbo Guo, Chen Song, Peng Xiao, Chengjun Zhou, Zhigang Xu, Jin-Peng Sun, Xiao Yu. Switching of the substrate specificity of protein tyrosine phosphatase N12 by cyclin-dependent kinase 2 phosphorylation orchestrating 2 oncogenic pathways. FASEB J. 2018 Jan;32(1):73-82. 

25. Huatang Zhang, Peng Xiao, Yin Ting Wong, Wei Shen, Mohit Chhabra, Raoul Peltier, Yin Jiang, Yonghe He, Jun He, Yi Tan, Yusheng Xie, Derek Ho, Yun-Wah Lam, Jinpeng Sun, Hongyan Sun. Construction of an alkaline phosphatase-specific two-photon probe and its imaging application in living cells and tissues. Biomaterials. 2017 Sep;140:220-229. 

26. Zhao Yang, Fan Yang, Daolai Zhang, Zhixin Liu, Amy Lin, Chuan Liu, Peng Xiao, Xiao Yu, Jin-Peng Sun. Phosphorylation of G Protein-Coupled Receptors: From the Barcode Hypothesis to the Flute Model. Mol Pharmacol. 2017 Sep;92(3):201-210. 

27. Chun-Hua Liu, Zheng Gong, Zong-Lai Liang, Zhi-Xin Liu, Fan Yang, Yu-Jing Sun, Ming-Liang Ma, Yi-Jing Wang, Chao-Ran Ji, Yu-Hong Wang, Mei-Jie Wang, Fu-Ai Cui, Amy Lin, Wen-Shuai Zheng, Dong-Fang He, Chang-Xiu Qu, Peng Xiao, Chuan-Yong Liu, Alex R B Thomsen, Thomas Joseph Cahill 3rd, Alem W Kahsai, Fan Yi, Kun-Hong Xiao, Tian Xue, Zhuan Zhou, Xiao Yu, Jin-Peng Sun. Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling. Nat Commun. 2017 Feb 9;8:14335. 

28. Lin Ge, Kang-Shuai Li, Meng-Meng Li, Peng Xiao, Xu-Ben Hou, Xu Chen, Hong-da Liu, Amy Lin, Xiao Yu, Gui-Jie Ren, Hao Fang, Jin-Peng Sun. Identification of a benzo imidazole thiazole derivative as the specific irreversible inhibitor of protein tyrosine phosphatase. Bioorg Med Chem Lett. 2016 Oct 1;26(19):4795-4798. 

29. Hui Li, Fan Yang, Chunhua Liu, Peng Xiao, Yunfei Xu, Zonglai Liang, Chuan Liu, Hongmei Wang, Wenjun Wang, Wenshuai Zheng, Wei Zhang, Xiaoyun Ma, Dongfang He, Xiaoyuan Song, Fuai Cui, Zhigang Xu, Fan Yi, Jin-Peng Sun, Xiao Yu. Crystal Structure and Substrate Specificity of PTPN12. Cell Rep. 2016 May 10;15(6):1345-58. 

30. Chang Pan, Jun-yi Tang, Yun-fei Xu, Peng Xiao, Hong-da Liu, Hao-an Wang, Wen-bo Wang, Fan-guo Meng, Xiao Yu, Jin-peng Sun. The catalytic role of the M2 metal ion in PP2Cα. Sci Rep. 2015 Feb 24;5:8560. 

31. Yanmei Zhang, Jiwei Zhang, Peng Xiao, Tianhong Wang, Yinbo QuImproved cellulase production via disruption of PDE01641 in cellulolytic fungus Penicillium decumbens. Bioresour Technol. 2012 Nov;123:733-7. 

32. Jiwei Zhang, Yinbo Qu, Peng Xiao, Xiaoyan Wang, Tianhong Wang, Feng HeImproved biomass saccharification by Trichoderma reesei through heterologous expression of lacA gene from Trametes sp. AH28-2. J Biosci Bioeng. 2012 Jun;113(6):697-703. 

33. Yaohua Zhong, Xuan Liu, Peng Xiao, Songhuan Wei, Tianhong Wang. Expression and secretion of the human erythropoietin using an optimized cbh1 promoter and the native CBH I signal sequence in the industrial fungus Trichoderma reesei. Appl Biochem Biotechnol. 2011 Nov;165(5-6):1169-77. 

学术奖励

肖鹏 (3/5), 靶向 G 蛋白偶联受体和磷酸酶的药理学研究, 山东省教育厅, 山东 省高等学校优秀科研成果奖，一等奖，2015 (孙金鹏，于晓，肖鹏, 庞琦，方浩）。