回国后作为通讯作者发表的论文

1. Ping YQ, Xiao P, Yang F, Zhao RJ, Guo SC, Yan X, Wu X, Zhao FH, Zhou FL, Xi YT, Yin WH, He FD, Zhang DL, Zhu ZL, Jiang Y, Torsten Schöneberg, Ines Liebscher#, Xu H. Eric#, Sun JP#. Structural basis for the tethered peptide activation of adhesion GPCRs. Nature（IF 46.486）. 2022. 2022 Apr;604(7907):763-770. doi: 10.1038/s41586-022-04619-y. 通讯作者

2. Xiao P, Guo SC, Wen X, He QT, Lin H, Huang SM, Gou L, Zhang C, Yang Z, Zhong YN, Yang CC, Li Y, Li SL, Tao XN, Yang ZS, Lu Y, He JY, Wang CX, Zhang L#, Kong LL#, Sun JP#, Yu X#. Tethered peptide activation mechanism of adhesion GPCRs ADGRG2 and ADGRG4. Nature（IF 46.486）. 2022 Apr;604(7907):771-778. doi: 10.1038/s41586-022-04590-8. 通讯作者

3. Cheng J, Yang Z, Ge XY, Gao MX, Meng R, Xu X, Zhang YQ, Li RZ, Lin JY, Tian ZM, Wang J, Ning SL, Xu YF, Yang F, Gu JK, Sun JP#, Yu X#. Autonomous sensing of the insulin peptide by an olfactory G protein-coupled receptor modulates glucose metabolism. Cell Metablism（IF 27.28）. 2022. 通讯作者（同期preview专题评论）

4. An W, Lin H, Ma L, Zhang C, Zheng Y, Cheng Q, Ma C, Wu X, Zhang Z, Zhong Y, Wang M, He D, Yang Z, Du L, Feng S, Wang C, Yang F, Xiao P#, Zhang P#, Yu X#, Sun JP#. Progesterone activates GPR126 to promote breast cancer development via the Gi pathway. Proc Natl Acad Sci USA. （IF 11.21）. 2022 Apr 12;119(15):e2117004119.doi: 10.1073/pnas.2117004119. 通讯作者

5. Yang F, Guo LL, Li Y, Wang GP, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu CX, Xu YF, Xiao P, Zhu ZL, Li ZJ, Zhou JY, Yu X, Gao N#, Sun JP#. Structure, function and pharmacology of human itch receptor complexes. Nature（IF 46.486）. 2021. 通讯作者

6. Ping YQ, Mao C, Xiao P, Zhao RJ, Jiang Y, Yang Z, An WT, Shen DD, Yang F, Zhang H, Qu C, Shen Q, Tian C, Li ZJ, Li S, Wang GY, Tao X, Wen X, Zhong YN, Yang J, Yi F, Yu X, Xu HE#, Zhang Y#, Sun JP#. Structures of the glucocorticoid-bound adhesion receptor GPR97-G_o complex. Nature（IF 46.486）. 2021 Jan;589(7843):620-626. 通讯作者 (获得Faculty 1000推荐）

7. Yang F, Mao C, Guo LL, Lin J, Ming Q, Xiao P, Wu X, Shen Q, Guo S, Shen DD, Lu R, Zhang L, Huang S, Ping Y, Zhang C, Ma C, Zhang K, Liang X, Shen Y, Nan F, Yi F, Luca VC, Zhou J, Jiang C, Sun JP#, Xie X#, Yu X#, Zhang Y#.  Structural basis of GPBAR activation and bile acid recognition. Nature（IF 46.486）. 2020 Nov;587(7834):499-504. doi: 10.1038/s41586-020-2569-1. 通讯作者

8. Xiao P, Yan W, Gou L, Zhong YN, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu CX, Yang X, Yang CC, Xia A, Hu Z, Zhang Q, He YH, Zhang DL, Zhang C, Hou GH, Liu H, Zhu L, Fu, Yang S, Daniel M. Rosenbaum, Sun JP#, Du Y#, Zhang L#, Yu X#, Shao Z#. Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes. Cell（IF 38.620）. 2021 Feb; doi: 10.1016/j.cell.2021.01.028. 通讯作者 （封面文章，专题推荐）

9. Yang F, Xiao P, Qu CX, Liu Q, Wang LY, Liu ZX, He QT, Liu C, Xu JY, Li RR, Li MJ, Li Q, Guo XZ, Yang ZY, He DF, Yi F, Ruan K, Shen YM, Yu X, Sun JP#, Wang JY#. Allosteric mechanisms underlie GPCR signaling to SH3-domain proteins through arrestin. (IF 13.99) Nat Chem Biol 2018 Sep;14(9):876-886. 通讯作者

10. Liu CH; Gong Z; Liang Zl; Liu ZX, Yang F, Sun YJ; Ma ML; Wang YJ; Xiao KH; Zhou Z; Yu X; Sun JP#; Arrestin biased GPCR agonism induces acute catecholamine secretion through TRPC3 coupling Nature communications. (IF 13.691)  2017 Feb 9;8:14335. doi: 10.1038/ncomms14335. 通讯作者 (获得Channels杂志的专题评论，Channels (Austin). 2017 May 1:1-3.).

11. Dong JH, Wang YJ, Cui M, Wang XJ, Zheng WS, Ma ML, He DF, Hu QX, Zhang DL, Ning SL, Liu CH, Wang C, Wang Y, Li XY, Lin A, Kahsai A, Cahill III T, Chen ZY, Yu X, Sun JP#. Adaptive activation of a stress response pathway improves learning and memory through Gs and β-arrestin-1 regulated lactate metabolism. Biol Psychiatry. (IF 12.069) 2017 Apr 15;81(8):654-670. 通讯作者（获得Faculty 1000推荐，封面文章）

12. Liu Q, He QT, Lyu X, Yang F, Zhu ZL, Xiao P, Yang Z, Zhang F, Yang ZY, Wang XY, Sun P, Wang QW, Qu CX, Gong Z, Lin JY, Xu Z, Song SL, Huang SM, Guo SC, Han MJ, Zhu KK, Chen X, Kahsai AW, Xiao KH, Kong W, Li FH, Ruan K, Li ZJ, Yu X, Niu XG, Jin CW, Wang J#, Sun JP# DeSiphering receptor core-induced and ligand-dependent conformational changes in arrestin via genetic encoded trimethylsilyl ¹H-NMR probe. Nat Commun. (IF 13.691) 2020 Sep 25;11(1):4857. doi: 10.1038/s41467-020-18433-5. （获得Faculty 1000推荐）

13. Yang F, Yu X, Liu C, Qu CX, Gong Z, Liu HD, Li FH, Wang HM, He DF, Yi F, Song C, Tian CL, Xiao KH, Wang JY#, Sun JP#. Phospho-selective mechanisms of arrestin conformations and functions revealed by unnatural amino acid incorporation and ¹⁹F-NMR. Nature Communications. (IF 13.691) 08 Sep 2015 doi:10.1038/ncomms9202通讯作者 （获得Faculty 1000推荐）

14. Li T, Yu B, Liu Z, Li J, Ma M, Wang Y, Zhu M, Yin H, Wang X, Fu Y, Yu F, Wang X, Fang X, Sun JP#, Kong Wei#. Direct Interaction and Dual Roles of Homocysteine on the Angiotensin II Type 1 Receptor in the Aggravation of Vascular Injury.  Nature Communications（IF 13.691）. 2018 Jan 2;9(1).

15. He QT, Xiao P, Huang SM, Jia YL, Zhu ZL, Lin JY, Yang F, Tao XN, Zhao RJ, Gao FY, Niu XG, Xiao KH, Wang JY#, Jin CW#, Sun JP#, Yu X#. Structures of arrestin2 bound to different phospho-barcodes and NMR characterization using DeSipher revealed the mechanism underlying the phospho-interaction-pattern-selective functions of arrestin. Nature Communications (IF 13.691). 2021, Accepted. 通讯作者

16.Fu Y, Huang Y, Yang Z, Chen Y, Zheng J, Mao C, Li Z, Liu Z, Yu B, Li T, Wang M, Xu C, Zhou Y, Zhao G, Jia Y, Guo W, Jia X, Zhang T, Li L, Liu Z, Guo S, Ma M, Zhang H, Liu B, Du J, Wang W, Tang C, Gao P, Xu Q, Wang X, Liu J, Sun JP#,, Kong W#. Cartilage oligomeric matrix protein is an endogenous β-arrestin-2-selective allosteric modulator of AT1 receptor counteracting vascular injury. Cell Res.(IF 20.396)2021 Jan 28. doi: 10.1038/s41422-020-00464-8.

17. Wang HM, Xu YF, Ning SL, Yang DX, Li Y, Du YJ, Yang F, Zhang Y, Liang N, Yao W, Zhang LL, Gu LC, Gao CJ, Pang Q, Chen YX, Xiao KH, Yu X#, Sun JP#. The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes. Cell Research. (IF 20.396)2014 Sep;24(9):1067-90. 通讯作者  (获得同期文章的专题评论)

18. Qu CX, Mao CY, Xiao P, Shen QY, Zhong YN, Yang F, Shen DD, Tao XN, Zhang HB, Yan X, Zhao RJ, He JY, Guan Y, Zhang C, Hou GH, Zhang PJ, Hou GG, Li ZJ, Yu X, Chai RJ#, Guan YF, Sun JP#, Zhang Y#. Ligand recognition, unconventional activation and G protein coupling of the prostaglandin E₂ receptor 2 (EP2). Science Advances (IF 13.116) 2021 Jan 12. doi:   通讯作者

19.Lu S, He X, Yang Z, Chai Z, Zhou S, Wang J, Rehman AU, Ni D, Pu J, Sun J#, Zhang J#. Activation pathway of a G protein-coupled receptor uncovers conformational intermediates as targets for allosteric drug design. Nat Commun. (IF 13.69) 2021 Aug 5;12(1):4721. 通讯作者

20. Qu CX, Park JY, Yun MW, He QT, Yang F, Kin K, Han D, Li R, T.M.Iverson, V V.Gurevich , Sun JP#, Chung KY#. Scaffolding mechanism of arrestin-2 in the cRaf/MEK1/ERK signaling cascade. Proc Natl Acad Sci U S A (IF 11.20). 2021 Sep 6 Vol. 118 通讯作者

21.Wang MW, Yang Z, Chen X, Zhou SH, Huang GL, Sun JN, Jiang H, Xu WM#, Lin HC#, Yu X#, Sun JP#. Activation of PTH1R alleviates epididymitis and orchitis through Gq and β-arrestin-1 pathways. Proc Natl Acad Sci U S A (IF 11.20). 2021 Sep 23 通讯作者

22. Lin JY, Cheng J, Du YQ, Pan W, Zhang Z, Wang J, An J, Yang F, Xu YF, Lin H, An WT, Wang J, Yang Z, Chai RJ, Sha XY, Hu H.L#, Sun JP#, Yu X#. In vitro expansion of pancreatic islet clusters facilitated by hormones and chemicals. Cell Discov. (IF 10.56) 2020 Apr 7;6:20. 通讯作者

23. Zhang H, Xiao P, Wong YT, Shen W, Chhabra M, Peltier R, Jiang Y, He Y, He J, Tan Y, Xie Y, Ho D, Lam YW#, Sun J#, Sun H#. Construction of an alkaline phosphatase-specific two-photon probe and its imaging application in living cells and tissues. Biomaterials.  (IF 12.47)2017 Sep;140:220-229.通讯作者

24. Han MJ, He QT, Yang M, Chen C, Yao Y, Liu X, Wang Y, Zhu ZL, Zhu KK, Qu C, Yang F, Hu C, Guo X, Zhang D, Chen C#, Sun JP# Wang J#. Single-molecule FRET and conformational analysis of beta-arrestin-1 through genetic code expansion and a Se-click reaction.Chem Sci. 2021 May 31;12(26):9114-9123.

25. Huang S, Xiao P, Sun J#. Structural basis of signaling of cannabinoids receptors: paving a way for rational drug design in controling mutiple neurological and immune diseases. Signal Transduct Target Ther. （IF 13.195） 2020 Jul 21;5(1):127. 通讯作者

26. Li H, Yang F, Liu CH, Xiao P, Xu YF, Liang ZL, Liu C, Wang HM, Wang WJ, Zheng WS, Zhang W, Ma XY, He DF, Song XY, Cui FA, Xu ZG, Yi F, Sun JP#, Yu X#. Crystal structure and substrate specificity of PTPN12. Cell Reports (IF 8.816). 2016 May 10;15(6):1345-58. 通讯作者

27. Zhang DL, Sun YJ, Ma ML, Wang YJ, Lin H, Li RR, Liang ZL, Gao Y, Yang Z, He DF, Lin A, Mo H, Lu YJ, Li MJ, Kong W, Chung KY, Yi F, Li JY, Qin YY, Li J, Thomsen ARB, Kahsai AW, Chen ZJ, Xu ZG, Liu M, Li D#, Yu X#, Sun JP#.Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility. Elife. (IF 8.508) 2018 Feb 2;7. pii: e33432. doi: 10.7554/eLife.33432.

28. Xu YF*#, Chen X#, Yang Z, Xiao P, Liu CH, Li KS, Yang XZ, Wang YJ, Zhu ZL, Xu ZG, Zhang S, Wang C, Song YC, Zhao WD, Wang CH, Ji ZL, Zhang ZY, Cui M*, Sun JP*, Yu X*. (2021) PTP-MEG2 regulates quantal size and fusion pore opening through two distinct structural bases and substrates. EMBO Reports. 2021, vol. 22,5 (2021): e52141. ( IF 8.80 ) 通讯作者

29. Wang HM, Dong JH, Li Q, Hu Q, Ning S, Zheng W, Chen TS, Xie X, Sun JP#, Yu X#. A stress response pathway upregulates somatostatin level and transcription in pancreatic delta-cells through Gs and β-arrestin1. Diabetologia. (IF 6.871) .2014 Sep;57(9):1899-910. doi: 10.1007/s00125-014-3290-0.通讯作者

30. Hou XB, Li R, Li KS, Yu X, Sun JP#, Fang H#. Fast Identification of Novel Lymphoid Tyrosine Phosphatase Inhibitors Using Target-Ligand Interaction-Based Virtual Screening. J. Med Chem. (IF 6.521). 2014 Nov 26;57(22):9309-22 PMID: 25372368. 通讯作者

31. Huang SM^(#), Yang F, Cai BY, He QT, Liu Q, Qu CX, Han MJ, Kong W, Jia YL, Li F, Yu X, Sun JP #, Wang J#. A Genetically Encoded Fluorescent Amino Acid for Monitoring Protein Interactions through FRET. Anal Chem. 2019 Oct 31. doi: 10.1021/acs.analchem.9b03305. (IF 6.642)

32. Li K, Hou X, Li R, Bi W, Yang F, Chen X, Xiao P, Liu T, Lu T, Zhou Y, Tian Z, Shen Y, Zhang Y, Wang J, Fang H, Sun JP#, Yu X# Identification and structure-function analyses of an allosteric inhibitor of the tyrosine phosphatase PTPN22.  J Biol Chem. (IF 4.297)2019 May 24;294(21):8653-8663. 通讯作者

33. Yang D, Xiao P, Li Q, Fu X, Pan C, Lu D, Wen S, Xia W, He D, Li H, Fang H, Shen Y, Xu Z, Lin A, Yu X, Wu JW#, Sun J#. Allosteric modulation of the catalytic VYD loop in Slingshot by its N-terminal domain underlies both Slingshot autoinhibition and activation. J Biol Chem. (IF 4.297)2018 Oct 19;293(42):16226-16241.通讯作者

34. Hu QX, Dong JH, Du H, Zhang DL, Ren HZ, Ma ML, Ci Y, Zhao TC, Yin XL, Yu X, Xut T, Xu ZG#, Sun JP#. Constitutive Gαi coupling activity of VLGR1 and its regulation by PDZD7. J Biol Chem. (IF 4.863)2014 Aug 29;289(35):24215-25.  通讯作者

35. Park JY, Qu CX, Li RR, Yang F, Yu X, Tian ZM, Shen YM, Cai BY, Yun Y, Sun JP#, Chung KY#Structural Mechanism of the Arrestin-3/JNK3 Interaction. Structure.(IF 4.831) 2019 Apr 16. pii: S0969-2126(19)30124-8. 通讯作者

36. Gong Q^*, Qin W^*, Xiao P^*, Wu X, Li L#, Zhang G, Zhang R, Sun J#, Yao SQ#, Huang W #. Internal Standard Fluorogenic Probe Based on Vibration-induced Emission for Visualizing PTP1B in Living Cells. Chem Commun (Camb). (IF 5.989)2019 Nov 6. doi: 10.1039/c9cc07680h. 通讯作者 （封面文章）

37. Ning SL, Zheng WS, Su J, Liang N, Dong JH, Zhang ZK, Cui M, Hu QX, Chen CC, Liu CH, Wang C, Pang Q, Chen YX, Yu X#, Sun JP#. Different downstream signaling of CCKAR regulates distinct functions of CCK in pancreatic β cells.  Br J Pharmacol. (IF 6.148). 2015 Nov;172(21):5050-67. 通讯作者

38. Zhang D, Wang Y, Lin H, Sun Y, Wang M, Jia Y, Yu X, Jiang H, Xu W, Sun J#, Xu Z Function and therapeutic potential of GPCRs in epididymis.Br J Pharmacol. (IF 6.148). 2020 Sep 9. doi: 10.1111/bph.15252通讯作者

39. J Liu, QX Li, XJ Wang, C Zhang, YQ Duan, ZY Wang, Y Zhang, X Yu, NJ Li, JP Sun#，F Yi#. β-Arrestins promote podocyte injury by inhibition of autophagy in diabetic nephropathy. Cell Death and Disease（IF 6.486） (2016) Apr 7;7: e2183; doi:10.1038/cddis.2016.89.通讯作者

40. Yang Z, Yang F, Zhang D, Liu Z, Lin A, Liu C, Xiao P, Yu X, Sun JP#. Phosphorylation of G protein-coupled receptors: from the barcode hypothesis to the flute model. Mol Pharmacol.(IF 3.904) 2017 Feb 28. pii: mol.116.107839. （封面文章）

41. Li H, Yang D, Ning S, Xu Y, Yang F, Yin R, Feng T, Han S, Guo L, Zhang P, Qu W, Guo R, Song C, Xiao P, Zhou C, Xu Z, Sun JP#, Yu X#. Switching of the substrate specificity of protein tyrosine phosphatase N12 by cyclin-dependent kinase 2 phosphorylation orchestrating 2 oncogenic pathways. FASEB J. (IF5.394)2018 Jan;32(1):73-82.

42. Pan C, Tang JY, Xu YF, Xiao P, Liu HD, Wang HA, Wang WB, Meng FG, Yu X#, Sun JP#. The catalytic role of the M2 metal ion in PP2Cα. Sci Rep. （IF5.597）2015 Feb 24;5:8560. doi: 10.1038/srep08560. 通讯作者

43. Xiao P, Wang X, Wang HM, Fu XL, Cui FA, Yu X, Wen SS, Bi WX#, Sun JP# The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop. IJBCB. (IF 4.595) 2014, 57 Dec, 84-95. 通讯作者

44. Wang XJ, Zhang DL, Xu ZG, Ma MM, Wang WB, Han XL, Huo YQ, Yu X#, Sun JP# Understanding CELSRs - Cadherin EGF LAG seven-pass G-type receptors. Journal of Neurochemistry.（IF 4.371） 2014 Dec;131(6):699-711. 通讯作者

45. Li R, Xie DD, Dong JH, Li H, Li KS, Su J, Chen LZ, Xu YF, Wang HM, Gong Z, Cui GY, Yu X, Wang K, Yao W, Xin T, Li MY, Xiao KH, An XF, Huo YQ, Xu ZG, Sun JP#, Pang Q#. Molecular mechanism of ERK dephosphorylation by striatal-enriched protein tyrosine phosphatase (STEP). Journal of Neurochemistry. 2014 Jan;128(2):315-29. (IF 4.371) 通讯作者 （获得Faculty 1000推荐）

46. Rostaminasab Dolatabad M, Guo LL, Xiao P, Zhu Z, He QT, Yang DX, Qu CX, Guo SC, Fu XL, Li RR, Ge L, Hu KJ, Hong-da L, Shen YM, Yu X, Sun JP#, Zhang PJ# Crystal structure and catalytic activity of the PPM1K N94K mutant. J Neurochem. (IF 4.371)2019 Feb;148(4):550-560.

47. Sun J#, Zhang D, Wang Y, Lin H, Yu X, Xu Z. The Role of G Protein-coupled Receptors in Cochlear Planar Cell Polarity. Int J Biochem Cell Biol.(IF 4.172) 2016 Aug;77(Pt B):220-5. 通讯作者兼第一作者

48. Li KS, Xiao P, Zhang DL, Hou XB, Ge L, Yang DX, Liu HD, He DF, Chen X, Han KR, Song XY, Yu X, Fang H, Sun JP# Identification of para-Substituted Benzoic Acid Derivatives as Potent Inhibitors of the Protein Phosphatase Slingshot. ChemMedChem(IF 3.113) 2015 Dec;10(12):1980-7. 通讯作者

49. Liu HD, Wang WB, Xu ZG, Liu CH, He DF, Du LP, Li MY, Yu X, Sun JP#. G protein-coupled receptor 120：A hot target for the development of anti-diabetic therapies. Eur J Pharmacol. (IF 3.266)2015 Sep 15;763(Pt B):160-8. 通讯作者

50. Pan C, Liu HD, Gong Z, Yu X, Hou XB, Xie DD, Zhu XB, Li HW, Tang JY, Xu YF, Yu JQ, Zhang LY, Fang H, Xiao KH, Chen YG, Wang JY, Pang Q, Chen W#, Sun JP#. Cadmium is a potent inhibitor of PPM phosphatases and targets the M1 binding site. Scientific Reports. (IF 4.576)2013;3:2333. 通讯作者

51. Li A, Yang D, Zhu M, Tsai KC, Xiao KH, Yu X, Sun J#, Du L#. Discovery of novel FFA4 (GPR120) receptor agonists with β-arrestin2-biased characteristics . Future Med Chem. (IF 4.065)2015 Dec;7(18):2429-37. 通讯作者

52. Li R, Gong Z, Pan C, Xie DD, Tang JY, Cui M, Xu YF, Yao W, Pang Q, Xu ZG, Li MY, Yu X#, Sun JP#. PPM1A functions as an ERK phosphatase. FEBS J. （IF 4.267）2013 Jun;280(11):2700-11. 通讯作者

53. Ge L, Li KS, Li MM, Xiao P, Hou XB, Chen X, Liu HD, Lin A, Yu X, Ren GJ, Fang H, Sun JP#. Identification of a benzo imidazol thiazol derivative as the specific irreversible inhibitor of protein tyrosine phosphatase. Bioorg Med Chem Lett.（IF 2.427）2016 Oct 1;26(19):4795-8. 通讯作者

54. Sun JP*#, Li R, Ren HZ, Xu AT, Yu X, Xu ZG#. The very large G protein coupled receptor (Vlgr1) in hair cells. J Mol Neurosci.（IF 2.662） 2013 May;50(1):204-14. 通讯作者兼第一作者

55. Xiao P, Yang L, Zhang C, Wang JY, Sun JP#. Discovery of GPCR superfamily and elucidation its working mechanisms and structures, to decode 2012 Nobel Prize in Chemistry. PIBB (IF 0.301)2012, 39(11): 1050-1060. 通讯作者

56. Dong JH, Chen X, Cui M, Yu X, Pang Q, Sun JP#. Beta2- Adrenergic Receptor and Astrocyte Glucose Metabolism. J Mol Neurosci. (IF2.662)2012 Oct;48(2):456-63. 通讯作者

57. Zhao S, Guo S, Yang C, Gong Z, Wang Y, Jia Y, Jiang X, Xu L, Shi L, Yu X, Sun J#., Zhang Y#., Chen X#. Cell active and functionally-relevant small-molecule agonists of calcitonin receptor.Bioorg Chem. 2020 Jan 21;96:103596. doi: 10.1016/j.bioorg.2020.103596.v (IF 4.567) 通讯作者

58. Sun Y, Zhang D, Ma ML, Lin H, Song Y, Wang J, Ma C, Yu K, An W, Guo S, He D, Yang Z, Xiao P, Hou G, Yu X#., Sun JP#. Optimization of a peptide ligand for the adhesion GPCR ADGRG2 provides a potent tool to explore receptor biology. J Biol Chem. （IF 4.237）2021;296:100174. 通讯作者

59. Lin JY, Yang Z, Yang C, Du JX, Yang F, Cheng J, Pan W, Zhang SJ, Yan X, Wang Jia, Wang Jin, Tie L, Yu X#, Chen X#, Sun JP#. An ionic lock and a hydrophobic zipper mediate the coupling between an insect pheromone receptor BmOR3 and downstream effectors. J Biol Chem.（IF 4.237）2021 Oct;297(4): 101160.通讯作者

第一作者及共同作者发表文章

 1. X Yu*, Sun JP*, Y He, X Guo, S Liu, B Zhou, A Hudmon, ZY Zhang. Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases. Proc. Natl. Acad. Sci. USA. (IF 10.6) 2007 Dec, 104, 19767-19772. Comment/ Reviews on this paper: http://www.f1000biology.com/article/1098405/evaluation共同第一作者

2. Sun JP*, Fedorov AA, Lee SY, Guo XL, Shen K, Lawrence DS, Almo SC, Zhang ZY. Crystal structure of PTP1B complexed with a potent and selective bidentate inhibitor. J Biol Chem. (IF 5.6) 2003 Apr 4; 278(14): 12406-14.  第一作者

3. Sun JP*, Luo Y*, Yu X, Wang WQ, Zhou B, Liang F, Zhang ZY. Phosphatase activity, trimerization, and the C-terminal polybasic region are all required for PRL1-mediated cell growth and migration. J Biol Chem. (IF 5.6) 2007 Sep 28;282(39):29043-51. 第一作者

4. Sun JP*, Wu L, Fedorov AA, Almo SC, Zhang ZY. Crystal structure of the Yersinia protein-tyrosine phosphatase YopH complexed with a specific small molecule inhibitor. J Biol Chem. (IF 5.6) 2003 Aug 29; 278(35): 33392-9.第一作者

5. Kotula JW*, Sun J* (Co-first author), Li M, Pratico ED, Fereshteh MP, Ahrens DP, Sullenger BA, Kovacs JJ. Targeted Disruption of β-Arrestin 2-Mediated Signaling Pathways by Aptamer Chimeras Leads to Inhibition of Leukemic Cell Growth. PLoS One. (IF 4.0) 2014 Apr 15;9(4):e93441. 共同第一作者

6. Sun JP*, Wang WQ*, Yang H, Liu S, Liang F, Fedorov AA, Almo SC, Zhang ZY. Structure and biochemical properties of PRL-1, a phosphatase implicated in cell growth, differentiation, and tumor invasion. Biochemistry. (IF 3.4) 2005 Sep 13; 44(36):12009-21. 共同第一作者

7. Strachan RT, Sun JP, Rominger DH, Violin JD, Ahn S, Thomsen AR, Zhu X, Kleist A, Costa T, Lefkowitz RJ. Divergent Transducer-Specific Molecular Efficacies Generate Biased Agonism At A G Protein-Coupled Receptor (GPCR). J Biol Chem. (IF 5.6) 2014 May 16;289(20):14211-24. PMID:24668815

8. Kahsai AW, Rajagopal S, Sun J, Xiao K. Monitoring protein conformational changes and dynamics using stable-isotope labeling and mass spectrometry (CDSiL-MS). Nature protocols. (IF 13.6) 2014 Jun;9(6):1301-19.

9. Cahill TJ 3rd, Thomsen AR, Tarrasch JT, Plouffe B, Nguyen AH, Yang F, Huang LY, Kahsai AW, Bassoni DL, Gavino BJ, Lamerdin JE, Triest S, Shukla AK, Berger B, Little J 4th, Antar A, Blanc A, Qu CX, Chen X, Kawakami K, Inoue A, Aoki J, Steyaert J, Sun JP, Bouvier M, Skiniotis G, Lefkowitz RJ. Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling, and endocytosis. Proc Natl Acad Sci U S A. (IF 10.6). 2017 Mar 7;114(10):2562-2567.

10. Li Q, Cui M, Yang F, Li N, Jiang B, Yu Z, Zhang D, Wang Y, Zhu X, Hu H, Li PS, Ning SL, Wang S, Qi H, Song H, He D, Li A, Zhang J, Liu F, Zhao J, Gao L, Yi F, Xue T, Sun JP, Gong Y#, Yu X#. (2017) A cullin 4B-RING E3 ligase complex fine-tunes pancreatic δ cell paracrine interactions. J Clin Invest. (IF 14.4). 2017 Jun 30;127(7):2631-2646.

11. Wang K, Zhu D, Yu X, Sun J, Yao W. Differences in the H2S-induced quantal release of catecholamine in adrenal chromaffin cells of neonatal and adult rats. Toxicology. (IF 4.1) 2013 Oct 4;312C:12-17.

12. Jiang H, Sun J, Xu Q, Liu Y, Wei J, Young CY, Yuan H, Lou H. Marchantin M: a novel inhibitor of proteasome induces autophagic cell death in prostate cancer cells. Cell Death Dis. (IF 6.5) 2013 Aug 8;4:e761.

13. Li F, Shi P, Li J, Yang F, Wang T, Zhang W, Gao F, Ding W, Li D, Li J, Xiong Y, Sun J, Gong W, Tian C, Wang J. A Genetically Encoded (19) F NMR Probe for Tyrosine Phosphorylation. Angew Chem Int Ed Engl. (IF 13.6); 2013 Apr 2;52(14):3958-62.

14. Zhu D, Yu X, Sun J, Li J, Ma X, Yao W.H(2)S induces catecholamine secretion in rat adrenal chromaffin cells. Toxicology. (IF 4.1) 2012 Dec 8;302(1):40-3.

15. Hou X, Li K, Yu X, Sun JP, Fang H. Protein Flexibility in Docking-based Virtual Screening: Discovery of Novel Lymphoid-specific Tyrosine Phosphatase Inhibitors using Multiple Crystal Structures. J Chem Inf Model. (IF 4.8) 2015 Sep 28;55(9):1973-83.

16. Liu J, Chen M, Yang F, Li R, Shi XR, Wang HM, Liu QJ, Yao W, Sun JP, Pang Q, Yu X. Biochemical and functional studies of Lymphoid-specific tyrosine phosphatase (Lyp) variants S201F and R266W. PLoS ONE. (IF 4.6) 2012;7(8):e43631. Epub 2012 Aug 27

17. Dou HQ, Xu YF, Sun JP, Shang S, Guo S,Zheng LH, Chen CC, Bruce IC, Zhou Z, Yu X Thiopental-induced insulin secretion via activation of IP3-sensitive calcium stores in rat pancreatic beta cells. Am J Physiol Cell Physiol. (IF 4.0); 2011 0363-6143 1522-1563

18. Kahsai AW, Xiao K, Rajagopal S, Ahn S, Shukla AK, Sun J, Oas TG, Lefkowitz RJ Multiple ligand-specific Conformations of the β2-Adrenergic Receptor, Nature Chemical Biology; (IF 16.1). 2011 Aug 21; 7(10):692-700.

19. Yu X, Chen M, Zhang S, Yu Z, Sun JP, Wang L, Liu S, Imasaki T, Takagi Y, and Zhang ZY Substrate specificity of lymphoid-specific tyrosine phosphatase (Lyp) and identification of SKAP-HOM as a Lyp substrate. J Biol Chem. (IF 5.6) 2011 Sep 2;286(35):30526-34.

20. Xiao K, Sun J, Kim J, Rajagopal S, Zhai B, Villén J, Haas W, Kovacs JJ, Shukla AK,Hara MR, Hernandez M, Lachmann A, Zhao S, Lin Y, Cheng Y, Mizuno K, Ma'ayan A, Gygi SP, Lefkowitz RJ. Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR). Proc. Natl. Acad. Sci. USA. (IF 10.6) 2010 Aug 107(34), 15299-15304.

21. Chen M, Sun JP, LIU J, Yu X. Research progress of several protein tyrosine phosphatases. Acta Physiologica Sinica. (IF 1.1) 2010 April, 25: 163-170

22. Lefkowitz RJ, Sun JP, Shukla AK. A crystal clear view of the beta2-adrenergic receptor. Nature Biotechnology. (IF 42.3) 2008 Feb;26(2):189-91.

23. Shukla AK, Sun JP, Lefkowitz RJ. Crystallizing thinking about the beta2-adrenergic receptor. Molecular Pharmacology. (IF 4.9) 2008 May; 73(5): 1333-8.

24. Liang F, Liang J, Wang WQ, Sun JP, Udho E, Zhang ZY. PRL3 promotes cell invasion and proliferation by down-regulation of Csk leading to Src activation. J Biol Chem. (IF 5.6) 2007 Feb 23;282(8):5413-9.

25. Liu S, Sun JP, Zhou B, Zhang ZY. Structural basis of docking interactions between ERK2 and MAP kinase phosphatase 3. Proc Natl Acad Sci U S A. (IF 10.6). 2006 Apr 4; 103(14):5326-31.

26. Wang WQ, Sun JP, Zhang ZY. An overview of the protein tyrosine phosphatase superfamily. Curr Top Med Chem. (IF 4.3) 2003; 3(7): 739-48.

27. Liu S, Zhu Z, Sun J, Zhu Z, Huang Q, Teng M, Niu L. Purification, crystallization and preliminary X-ray crystallographic analysis of agkaggregin, a C-type lectin-like protein from Agkistrodon acutus venom. Acta Crystallogr D Biol Crystallogr. (IF 5.3) 2002 Apr; 58(Pt 4): 675-8.

28. Xu H, Li Q, Liu J, Zhu J, Li L, Wang Z, Zhang Y, Sun Y, Sun J, Wang R, Yi F. β-Arrestin-1 deficiency ameliorates renal interstitial fibrosis by blocking Wnt1/β-catenin signaling in mice. J Mol Med (Berl). (IF 5.1) 2018 Jan;96(1):97-109.

29. Xiao K, Sun J. Elucidating structural and molecular mechanisms of β-arrestin-biased agonism at GPCRs via MS-based proteomics. Cell Signal. (IF 4.1) 2018 Jan;41:56-64.

30. Nair A, Chung H, Sun T, Tyagi S, Dobrolecki LE, Rocio DV, Kurley SJ, Orellana M, Renwick A, Henke DM, Katsonis P, Chan DW, Li H, Mao S, Petrovic I, Creighton CJ, Gutierrez C, Dubrulle J, Stossi F, Tyner JW, Lichtarge O, Lin CY, Scott KL, Hilsenbeck SG, Sun J, Yu X, Osborne C. K, Schiff R, Christensen JG, Shields DJ, Rimawi MF, Ellis MJ, Shaw CA, Lewis MT, Westbrook TF. Targeting receptors that share the feedback inhibitor PTPN12 leads to broad spectrum therapeutic suppression of triple-negative breast cancer. Nature Medicine. (IF 36.2) 2018 May;24(4):505-51

31. Fang W, Wang Z, Li Q, Wang X, Zhang Y, Sun Y, Tang W, Ma C, Sun J, Li N, Yi F. Gpr97 Exacerbates AKI by Mediating Sema3A Signaling.J Am Soc Nephrol. (IF 9.3) 2018 May;29(5):1475-1489.

32. Li N, Yang Z, Li Q, Yu Z, Chen X, Li JC, Li B, Ning SL, Cui M, Sun JP, Yu X. Ablation of somatostatin cells leads to impaired pancreatic islet function and neonatal death in rodents. Cell Death Dis. (IF 6.5)2018 Jun 7;9(6):682.

33. Hou X, Rooklin D, Yang D, Liang X, Li K, Lu J, Wang C, Xiao P, Zhang Y, Sun JP, Fang H Computational Strategy for Bound State Structure Prediction in Structure-Based Virtual Screening: A Case Study of Protein Tyrosine Phosphatase Receptor Type O Inhibitors. J Chem Inf Model. (IF 4.8) 2018 Nov 26;58(11):2331-2342.

34. Yang J, Yin HS, Cao YJ, Jiang ZA, Li YJ, Song MC, Wang YF, Wang ZH, Yang R, Jiang YF, Sun JP, Liu BY, Wang C. Arctigenin Attenuates Ischemia/Reperfusion Induced Ventricular Arrhythmias by Decreasing Oxidative Stress in Rats. Cell Physiol Biochem. (IF 4.4) 2018;49(2):728-742.

35. Du H, Zou L, Ren R, Li N, Li J, Wang Y, Sun J, Yang J, Xiong W, Xu Z. Lack of PDZD7 long isoform disrupts ankle-link complex and causes hearing loss in mice. FASEB J. (IF 5.4) 2020 Jan;34(1):1136-1149.

36. Hou X, Sun JP, Ge L, Liang X, Li K, Zhang Y, Fang H. Inhibition of Striatal-Enriched Protein Tyrosine Phosphatase by Targeting Computationally Revealed Cryptic Pockets. Eur J Med Chem. (IF 5.6) 2020 Mar 15;190:112131.

37. Lu Z, Xiao P, Zhou Y, Li Z, Yu X, Sun J, Shen Y, Zhao B. Identification of HN252 as a potent inhibitor of protein phosphatase PPM1B. J Cell Mol Med. (IF 4.5) 2020 Oct 13;24(22):13463-71

38. Wang J, Zhang J, Lin X, Wang Y, Wu X, Yang F, Gao W, Zhang Y, Sun J, Jiang C, Xu M. DCA-TGR5 signaling activation alleviates inflammatory response and improves cardiac function in myocardial infarction.J Mol Cell Cardiol. (IF 5.1) 2020 Oct 31;151:3-14.

39. Fu Y, Sun Y, Wang M, Hou Y, Huang W, Zhou D, Wang Z, Yang S, Tang W, Zhen J, Li Y, Wang X, Liu M, Zhang Y, Wang B, Liu G, Yu X, Sun J, Zhang C, Yi F. Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism.Cell Metab. (IF 24.3) 2020 Dec 1;32(6):1052-1062.

40. 李慧，郑文帅，龚正，孙金鹏#. 从医生到杰出科学家: 山东大学学报医学版 2012 12; 50(No.12): 1-9通讯作者

41. 李慧，孙金鹏#. 生命中的两次召唤: 山东大学学报医学版 2012 12; 50(No.12): 10-11通讯作者

42. 孙金鹏#.化学奖-膜受体蛋白的马拉松科学FANS 2012.12 13-14通讯作者

43. 谢迪东，龚正，李容，李慧，刘宏达，孙金鹏#，庞琦#. 磷酸酶STEP的Q-loop中T541参与催化反应的机制. 山大学报 2013.8通讯作者

44. 杨笃晓，孙金鹏#.现代药靶的核心分子G蛋白偶联受体科学发展报告 2013. 88-96. 通讯作者

45. 肖鹏，孙金鹏，裴钢. G蛋白偶联受体结构分析的近年进展新生物学年鉴.

46. Yu Y, Yang J, Luan F, Gu G, Zhao R, Wang Q, Dong Z, Tang J, Wang W, Sun J, Lv P, Zhang H, Wang C. Sensorineural Hearing Loss and Mitochondrial Apoptosis of Cochlear Spiral Ganglion Neurons in Fibroblast Growth Factor 13 Knockout Mice. Front Cell Neurosci. (IF 5.57) 2021 Jun 16;15:658586.

47. Chao ML, Luo S, Zhang C, Zhou X, Zhou M, Wang J, Kong C, Chen J, Lin Z, Tang X, Sun S, Tang X, Chen H, Wang H, Wang D, Sun JP, Han Y, Xie L, Ji Y. S-nitrosylation-mediated coupling of G-protein alpha-2 with CXCR5 induces Hippo/YAP-dependent diabetes-accelerated atherosclerosis. Nat Commun. (IF 15.8) 2021 Jul 22;12(1):4452.

48. Mao C, Ma Z, Jia Y, Li W, Xie N, Zhao G, Ma B, Yu F, Sun J, Zhou Y, Cui Q, Fu Y, Kong W.  Nidogen-2 Maintains the Contractile Phenotype of Vascular Smooth Muscle Cells and Prevents Neointima Formation via Bridging Jagged1-Notch3 Signaling. Circulation. (IF 27.47) 2021 Jul 28.

49. Zhang G, Li D, Tu C, Meng L, Tan Y, Ji Z, Cheng J, Lu G, Lin G, Zhang H, Sun J, Wang M, Du J, Xu W. Loss-of-function missense variant of AKAP4 induced male infertility through reduced interaction with QRICH2 during sperm flagella development. Hum Mol Genet. (IF 6.13)2021 Aug 20;ddab234.

50. Zhang H, Chen LN, Yang D, Mao C, Shen Q, Feng W, Shen DD, Dai A, Xie S, Zhou Y, Qin J, Sun JP, Scharf DH, Hou T, Zhou T, Wang MW, Zhang Y. Structural insights into ligand recognition and activation of the melanocortin-4 receptor. Cell Res. (IF 25.92) 2021 Aug 25.

部分大会口头报告及特邀报告：

Sun JP (2004) Structure Basis of Specific Inhibition of Yersinia Protein-tyrosine Phosphatase 2004ASBMB annual Meeting, Boston. (Selected honored student talk)

Sun JP (2011) Dissecting Ligand Specific Severn Trans-membrane Receptor Signaling Complexes 2011 BIT's 3^rd International Congress of Antibodies March 23 Track 2-1

孙金鹏 (2011) PEST蛋白质酪氨酸磷酸酶底物特异性的分子基础第十届全国酶学学术讨论会

孙金鹏 (2012) GPCR的工作原理，解读2012年诺贝尔化学奖内蒙古大学

Sun JP (2012) Decoding the HER2 C-terminal tyrosine phosphorylation barcode.  Symposium of receptors, associated to 2012 Nobel Chemistry Prize.

孙金鹏 (2014) G蛋白偶联受体的偏向性信号转导 北京大学化学与生物技术学院（深圳）

孙金鹏 (2014) PEST domain containing phosphatases.中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议青年科学家论坛（厦门），并获得一等奖

Sun JP  (2014) Regulation of the islet homeostasis by β-adrenergic receptors. （Xiamen） The 4th Workshop on the Hippo pathway

孙金鹏（2014）：G 蛋白偶联受体在听觉和胰岛功能中的研究 双清论坛第125期，重大疾病导向的G蛋白偶联受体结构、功能和新配体发现研究 专题报告

孙金鹏（2014）：G蛋白偶联受体在胰岛功能中的研究 第五届山东省生物化学与分子生物学大会，专题报告

孙金鹏（2015）: G蛋白偶联受体的磷酸化编码介导的信号转导机制 (Phospho-decision mechanism of specific arrestin conformations and functions: The music of the receptor revealed by unnatural amino acid incorporation and ¹⁹F-NMR) 泛环渤海生物化学与分子生物学会, 专题报告

孙金鹏 （2015）: G蛋白偶联受体的磷酸化编码 (Phospho-barcoding of the GPCRs). 第九届全国化学生物学会议， 邀请报告

孙金鹏 （2016）: Arrestin介导的G蛋白偶联受体的偏向性信号转导-一个笛子模型。中国病理生理学会第十三届受体和信号转导专业委员会学术会议

孙金鹏 （2017）Arrestin介导的G蛋白偶联受体的偏向性信号转导机制及药理学应用。 第十五届全国生化与分子药理学学术会议

孙金鹏  (2021) : G蛋白偶联受体配体识别和信号转导的多样性。高等医学研究院2021年学术年会

Sun JP（2017） A new connection between the GPCR and channel through arrestin. 19th International Symposium on Chromaffin Cell Biology

Sun JP（2017）Biased GPCR signaling in the drug development 首届中国大连受体会议

Sun JP（2017）靶向GPCR偏向性途径的肾脏病药物发现 第一届全国肾脏药理学学术会议

Sun JP（2017）Mechanism of GPCR phospho-coding and its application in new drug discovery 2017 Asian Federation for Pharmaceutical Sciences Conference （AFPS2017）

Sun JP（2017）听觉中G蛋白偶联受体的相关研究 第十五届中国生物物理年会，听觉分会

Sun JP（2017）Arrestin mediated GPCR biased signaling and its application in new drug discovery The 2^nd CNPHARS-ASPET Joint Symposia on Pharmacology第二届中-美药理学双边学术会议